Treatment of acetylcholinesterase inhibitor-induced seizures with polytherapy targeting GABA and glutamate receptors
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چکیده
منابع مشابه
Characterization of receptors for glutamate and GABA in retinal neurons.
Glutamate and gamma-aminobutyric acid (GABA) are major excitatory and inhibitory neurotransmitters in the vertebrate retina, "a genuine neural center" (Ramón y Cajal, 1964, Recollections of My Life, C.E. Horne (Translater) MIT Press, Cambridge, MA). Photoreceptors, generating visual signals, and bipolar cells, mediating signal transfer from photoreceptors to ganglion cells, both release glutama...
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Autism is a severe neuropsychiatric disorder characterized by impaired communication, significant reduction in social interaction, and repetitive and stereotyped behaviour. It is highly hereditable (Hoekstra et al., 2007); however, genomic alterations associated to autism have been found only in less than a fifth of the total number of cases. How those alterations ultimately cause the autistic ...
متن کاملترکیبات ارگانوفسفره و سیستم گابائرژیک مغز
Organophosphorus (OP) compounds are cholinesterase inhibitors widely used as pesticides in agriculture and nerve agents in battlefields. Exposure to these compounds leads to accumulation of acetylcholine at cholinergic synapses and overstimulation of muscarinic and nicotinic receptors by inhibiting the enzyme acetylcholinesterase. Seizure activity is one of the major manifestations of OP poison...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2021
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2020.108444